Almost one quarter of Americans regularly "take drugs to affect their mood and help them relax" according to the latest poll by Gallup; but which states are the most (and least) medicated? click image for large legible version... As Gallup notes, West Virginians are most likely to report near-daily use of drugs or medications that alter their mood or help them relax, followed by residents of Rhode Island. Southern states make up six of the top 10 highest drug use states, while Alaskans, Wyomingites and Californians are least likely to say they use such drugs almost every day. Source: Gallup